Pordenone was a painter of large-scale altarpieces and murals for churches. He was born and trained in Pordenone, a small town on the Venetian mainland from which he took his name, and he spent most of his early career there. As his reputation grew, he began to receive a number of important commissions from churches in other regions of Italy. He visited Rome around 1516, where he had the opportunity to study the early work of Raphael and Michelangelo. From 1527 until his death he spent most of his time in Venice, where he worked on various projects including the fresco decorations in San Rocco, Santo Stefano, and Palazzo d’Anna.