Domenico, whose family was of German extraction, was born in Venice. He became the pupil and adopted son of Giulio Campagnola, under whose influence he acquired what was to become a lifelong interest in printmaking. Although Domenico was a proficient painter, he was an extremely talented graphic artist and a prolific draughtsman with a particular interest in landscapes. Many of his drawings display his awareness of Titian’s landscape drawings. Domenico also admired Titian’s woodcuts and began to design his own, which he cut himself rather than rely on a professional block cutter. Domenico had left Venice by 1531, and spent the later part of his career in Padua.