St Jerome on a cloud is guided heavenwards by a guardian angel. His hand rests on a skull, symbolizing the transience of earthly life. The painting was made for an altar in the nave of the popular Venetian church of Santa Maria dei Miracoli. The church was run by Franciscan nuns and in the foreground is a Franciscan friar who can be identified as the renowned sixteenth-century Spanish preacher St Peter of Alcantara. He emphasizes the spiritual character of the event, experiencing the vision of St Jerome inwardly. The altarpiece, which was painted around 1725, was originally arched at the top.